Article Archives

Part 1 of this article discussed the impact of multiplexing morphological methods, multiparametric techniques, and supervised machine-learning to answer the question "what" is there, as well as "where... read more

The first commercial liquid chromatograph was probably an amino acid analyzer. These ion exchange chromatographs were so specialized that they had almost no impact on chemical analysis outside of ... read more

Many protein detection methods, including Western blotting, flow cytometry, ELISA, and immunohistochemistry, require the use of target-specific probes, such as antibodies, that are detected via two-... read more

Key protein complexes are fundamental to a wide range of cellular processes and key metabolic pathways within the body. Their dysfunction is associated with a range of disease pathologies such as ... read more

Synthetic biology is defined as the de novo design and construction of biological devices and systems, and as such is heavily reliant on the use of synthetic DNA. The size and sequence of potential ... read more

The invention of the polymerase chain reaction (PCR) in the early 1980s revolutionized molecular biology and molecular medicine. Since then, PCR has developed into a widely used technique for ... read more

The proliferation of forensic DNA testing and databases by state and local jurisdictions was recently reported by Joseph Goldstein in The New York Times. For years, the FBI’s combined indexing system ... read more

According to the Occupational Safety and Health Administration (OSHA), on average, it takes between 18 and 36 months to develop and implement a new regulation, trailing the pace of science. As a ... read more

Precise and biologically relevant in vitro studies require the ability to analyze cell responses to perturbations over time. In order to achieve successful long-term cell culture and imaging, however,... read more

Traditional RNA detection methods, which analyze RNA levels in lysed, permeabilized, or fixed cell samples, make it challenging to understand the role of one gene in the context of a tissue, organ, or... read more